PGx

Gene copy number variation analysis reveals dosage-insensitive expression of CYP2E1.

Gene copy number variants (CNVs) of CYP2E1 have been described but not functionally characterized. Here we investigated effects of CNVs on hepatic and lymphoblastoid CYP2E1 expression. Using available single-nuleotide polymorphism microarray data and …

Genetics, epigenetics, and regulation of drug-metabolizing cytochrome p450 enzymes.